Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat.

نویسندگان

  • K Sakaguchi
  • M Tanaka
  • T Ohkubo
  • H Yoshizato
  • Y Hanai
  • T Fujikawa
  • H Kaneko
  • K Nakashima
چکیده

GH is involved in growth and development in vertebrates [1]. The actions of GH are initiated by its binding to the specific GH-receptors (GH-R) localized in the cell membrane of target tissues [2]. GH also binds to a soluble GH-binding protein (GH-BP) in serum [3]. The GH-BP is generated from a variant mRNA resulting from an alternative splicing of GH-R mRNA precursor at the exon 7-8 boundary [4]. It has been reported that the expression of GH-R and GH-BP mRNAs increases in pregnant mouse liver, and it decreases gradually in the mammary

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Expression of growth hormone gene during early development of Siberian sturgeon (Acipenser baerii)

The mRNA expression of growth hormone (GH) gene in early development stages of Siberian sturgeon was investigated using RT-PCR method. Samples were collected from unfertilized eggs up to 50 days post hatched (dph) larvae in 11 different times. Ribosomal protein L6 (RPL6) transcripts were used as the internal standard during quantification of GH mRNA expression. The results showed that the GH mR...

متن کامل

Transcription of growth hormone mRNA as a molecular marker of egg quality in Siberian sturgeon (Acipenser baerii)

The Siberian sturgeon (Acipenser baerii) is an economically important species. Sturgeon stockassessment during fingerling production is considered to be one of the most difficult phases ofhatchery rearing. The present study investigated the expression of growth hormone (GH)mRNA in unfertilized eggs, fertilized eggs, eyed eggs (2 day before hatching), non-viable eggsand newly-hatched Siberian st...

متن کامل

P-205: Production of Recombinant Fish FSH Hormone in Pichia Pastoris

Background: Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones that composing alpha and beta subunits with non-covalently bonds. This hormone involve in regulation of the reproductive processes such as gamete generation and follicular growth. Injection of the hormone in most of fish species increases 17 beta-estradiol production by ovarian tissue and also stimulat...

متن کامل

The relationship between growth hormone polymorphism and growth hormone receptor genes with milk yield and reproductive performance in Holstein dairy cows

The aim of this study was to investigate the potential association between growth hormone GH/AluI and growth hormone receptor GHR/AluI polymorphisms with milk yield and reproductive performances in Holstein dairy cows in Iran. Blood samples of 150 Holstein cows were collected and their genomic DNA was extracted using Gene-Fanavaran DNA extracting kit. Fragments of the 428 bp of exon 5 growth ho...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Endocrine journal

دوره 45 Suppl  شماره 

صفحات  -

تاریخ انتشار 1998