Tissue-specific regulation of growth hormone receptor and growth hormone binding protein gene expression during pregnancy and lactation in the rat.
نویسندگان
چکیده
GH is involved in growth and development in vertebrates [1]. The actions of GH are initiated by its binding to the specific GH-receptors (GH-R) localized in the cell membrane of target tissues [2]. GH also binds to a soluble GH-binding protein (GH-BP) in serum [3]. The GH-BP is generated from a variant mRNA resulting from an alternative splicing of GH-R mRNA precursor at the exon 7-8 boundary [4]. It has been reported that the expression of GH-R and GH-BP mRNAs increases in pregnant mouse liver, and it decreases gradually in the mammary
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ورودعنوان ژورنال:
- Endocrine journal
دوره 45 Suppl شماره
صفحات -
تاریخ انتشار 1998